The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from de novo mutations in variant-intolerant genes. We hypothesize […]
Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully […]
The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of […]
To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail […]
It is highly desirable to discover photovoltaic mechanisms that enable a higher efficiency of solar cells. Here, we report that the bulk photovoltaic effect, […]
Flatworms of the species Schmidtea mediterranea are immortal—adult animals contain a large pool of pluripotent stem cells that continuously differentiate […]
The transcriptome of a cell dictates its unique cell-type biology. We used single-cell RNA sequencing to determine the transcriptomes for essentially every […]
RNA promotes liquid-liquid phase separation (LLPS) to build membraneless compartments in cells. How distinct molecular compositions are established and […]
Mitochondrial ATP synthase comprises a membrane embedded Fo motor that rotates to drive ATP synthesis in the F1 subunit. We used single-particle cryo-EM to […]
Prion-like RNA binding proteins (RBPs) such as TDP-43 or FUS are largely soluble in the nucleus, but form solid pathological aggregates when mislocalized to […]
Extreme stresses can be produced in nanoscale structures, a feature which has been used to realize enhanced materials properties, such as the high mobility of […]
Chemical reactions typically proceed via stochastic encounters between reactants. Going beyond this paradigm, we combine exactly two atoms into a single, […]
Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine […]
Our understanding of kidney disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ’s […]
Basic heteroarenes are a ubiquitous feature of pharmaceuticals and bioactive molecules, and Minisci-type additions of radical nucleophiles are a leading method […]
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, presenting a potential therapeutic target in autoimmune […]
Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells whose function is poorly understood. Here we show that Ascl1-mutant mice which have no […]
In modern microelectronic devices, hot electrons accelerate, scatter, and dissipate energy in nanoscale dimensions. Despite recent progress in nanothermometry, […]
Why are some visual stimuli consciously detected, while others remain subliminal? We investigated the fate of weak visual stimuli in the visual and frontal […]
In August 2017, the Gulf of Mexico’s hypoxic zone was declared to be the largest ever measured. It has been estimated that a 60% decrease in watershed […]
During animal regeneration cells must organize into discrete and functional systems. We show that self-organization, along with patterning cues, govern […]
Armed with new data, archaeologists are revealing that mind-altering drugs were present at the dawn of the first complex societies some 5000 years ago in the […]
Geneticists and anthropologists studying historical records and modern-day genomes are finding traces of previously unknown migrants to Latin America in the […]
Two of the world’s most famous research chimpanzees have finally retired. Hercules and Leo arrived at a chimp sanctuary in Georgia last week. Sarah […]
Did people domesticate animals? Or did they domesticate themselves? Online News Editor David Grimm talks with Sarah Crespi about a recent study that looked at […]
David Grimm—online news editor for Science—talks with Sarah Crespi about the chance a naked mole rat could die at any one moment. Surprisingly, the […]
Freelance science writer Michael Price talks with Sarah Crespi about recently revealed deliberations for a coveted mathematics prize: the Fields Medal. […]
Whales and dolphins have incredibly sensitive hearing and are known to be harmed by loud underwater noises. David Grimm talks with Sarah Crespi about new […]
This week, three papers came out describing new approaches to folding DNA into large complex shapes—20 times bigger than previous DNA sculptures. Staff […]
The abominable snowman, the yeti, bigfoot, and sasquatch—these long-lived myths of giant, hairy hominids depend on dropping elusive clues to stay in the […]
The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from de novo mutations in variant-intolerant genes. We hypothesize […]
Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully […]
The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of […]
A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver […]
The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science […]
Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to promote the differentiation of effector CD8+ cytotoxic […]
It has long been appreciated that most autoimmune disorders are characterized by increased prevalence in females, suggesting a potential role for sex hormones […]
Nicole De Nisco and Kim Orth explain that the type 3 secretion system 1 of Vibrio parahaemolyticus initially rewires host cell signaling networks to promote […]
Jonathan Jaggar explains how trafficking of regulatory subunits fine-tunes the activity of BK channels in arterial myocytes to limit vasoconstriction. […]
Johannes Hell and Manuel Navedo explain that modification of a particular serine residue affects the activity of the L-type calcium channel Cav1.2 in the brain […]
Bridget Wilson explains that transient homotypic interactions between pre-B cell receptors promotes survival of acute lymphoblastic leukemia cells. […]
Adam Schrum and Steven Neier describe a technique for identifying patient-specific protein complexes and how it revealed altered signaling in T cells from […]
Steven Wiley describes a quantitative study that shows that adaptor proteins, not core signaling components, control the flow of information through the EGF […]
Diagnosis marks the beginning of any successful therapy. Because many medical conditions progress asymptomatically over extended periods of time, their timely […]
A key enzyme in cholesterol synthesis is placed firmly on the oncogenic map and demonstrated to be a potential therapeutic target in liver cancer by […]
Duchenne muscular dystrophy (DMD) is a lethal hereditary muscle disease caused by mutations in the gene encoding the muscle protein dystrophin. These mutations […]
The persistence of HIV reservoirs, including latently infected, resting CD4+ T cells, is the major obstacle to cure HIV infection. CD32a expression was […]
A transient 3-day course of treatment with a histone deacetylase inhibitor persistently rescues atypical social behavior in a Shank3-deficiency mouse model of […]
Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms […]